Absolute Configuration of L-Methionine Sulfoximine as a Toxic Principle in Cnestis palala (LOUR.) MERR.

L-methionine sulfoximine as a novel selection agent for genetic transformation of orchids.

A key challenge in molecular breeding of orchids is the creation of efficient and reproducible gene transformation systems. In this study, we report a new transformation method utilizing L-methionine sulfoximine (MSO) as a novel agent for selection of transgenic Dendrobium hybrids D. Madame Thong-In and D. Chao Praya Smile with the bialaphos resistance (bar) gene as a selectable marker. Gene tr...

Inhibition of glutamine synthetase by methionine sulfoximine. Studies on methionine sulfoximine phosphate.

The irreversible inhibition of glutamine synthetase by methionine sulfoximine is associated with the tight binding to the enzyme of adenosine diphosphate and methionine sulfoximine phosphate; the latter compound can be cleaved nonenzymatically and also by phosphatases to equimolar amounts of methionine sulfoximine and inorganic phosphate. Methionine sulfoximine phosphate is oxidized by L-amino ...

Binding enthalpies for glutamine synthetase interactions with L-S- and L-R-diastereoisomers of the substrate analog L-methionine sulfoximine.

L-Methionine SR-sulfoximine-resistant glutamine synthetase from mutants of Salmonella typhimurium.

Two mutants of Salmonella typhimurium resistant to growth inhibition by the glutamine synthetase transition state analog, L-methionine SR-sulfoximine, were isolated and characterized. These mutants are glutamine bradytrophs and cannot use growth rate-limiting nitrogen sources. Although this phenotype resembles that of mutants with lesions in the regulatory gene for glutamine synthetase, glnG, t...

Absolute configuration of xerophenone A

The title compound, C(33)H(42)O(5), known as xerophenone A {systematic name: (1R,3R,4R,6S,8E,10R)-10-hy-droxy-8-[hy-droxy(phen-yl)methyl-ene]-4-methyl-1,6-bis-(3-methyl-but-2-en-1-yl)-3-(3-methyl-but-3-en-1-yl)-11-oxatricyclo-[4.3.1.1(4,10)]undecane-7,9-dione} is a naturally occurring rearranged benzophenone compound which was isolated from the twigs of Garcinia propinqua. The absolute configur...